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Department of Bioinformatics and Structural Biochemistry
Institute of Biochemistry
Short link:
https://eeris.eu/
ERIF-2000-000Y-1036
1116
Visits
The Department of Bioinformatics and Structural Biochemistry (DBSB) was established in 1999 with the mission to develop and implement bioinformatics and biocomputing techniques and use them to guide experimental research in molecular life sciences. Currently DBSB covers two main research areas: (a) structure-function oriented bioinformatics and biocomputing and (b) systems and network biology techniques in aging research and age related disease More details related to ...
Andrei-Jose
Petrescu
andrei.petrescu@biochim.ro
Dr
SCIENTIFIC TEAM
12
Floriana S. BECTAS
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Gabriela BUNU
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Eliza C. MARTIN
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Ioana MILITARU
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Cristian MUNTEANU
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Andrei-Jose PETRESCU
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Andrei-Jose PETRESCU
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Laurentiu SPIRIDON
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Petrescu STEFANA
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Teodor A. SULEA
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Robi TACUTU
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Victor G. UNGUREANU
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Genomic, Transcriptomic, Proteomics and Metabolomics Facilities
RI Domain of activity
Bio-Informatics Facilities
RI Domain of activity
Centralised Computing Facilities
RI Domain of activity
Molecular Modeling, Design and Simulation
RI Domain of activity
Type Of RI:
Single sited RI
RI Life Cycle Status:
Active RI
Research Data Management Plan:
No information available
Access Policy to Research Infrastructure and Related Services:
No information available
Research Services
Proteome, Interactome and Post-Tanslational Modification Analysis
SERVICE DESCRIPTION:
We provide assistance in proteome, interactome and PTM Analysis
SERVICE PERSONS:
Cristian MUNTEANU
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Bioinformatics and Biomolecular Database Development
SERVICE DESCRIPTION:
We provide assistance in bioinformatics and biomolecular database development
SERVICE PERSONS:
Andrei-Jose PETRESCU
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Eliza C. MARTIN
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Laurentiu SPIRIDON
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Floriana S. BECTAS
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In Silico Drug Design
SERVICE DESCRIPTION:
We provide assistance in biomolecular and drug design
SERVICE PERSONS:
Andrei-Jose PETRESCU
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Eliza C. MARTIN
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Laurentiu SPIRIDON
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Victor G. UNGUREANU
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Teodor A. SULEA
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Biomolecular Modeling and Simulation
SERVICE DESCRIPTION:
We assist and complement experimental work with biomolecular modelling and simulation techniques
SERVICE PERSONS:
Andrei-Jose PETRESCU
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Eliza C. MARTIN
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Laurentiu SPIRIDON
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Victor G. UNGUREANU
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Teodor A. SULEA
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MS based Biological and Chemical Compound Identification
SERVICE DESCRIPTION:
We provide assistance in biological and chemical compound identification.
SERVICE PERSONS:
Cristian MUNTEANU
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Proteomic analysis system for melanoma biomarkers
SERVICE DESCRIPTION:
We provide full service starting with project design and sample preparation from cells or tissue. Using our nanoLC-MS LTQ-Orbitrap Velos instrument we can provide proteome analysis of melanoma samples and screen for potential melanoma biomarkers. For more advanced investigations we can identify molecular targets for therapy, including development of new targets to overcome resistance to chemotherapy.
SERVICE PERSONS:
Petrescu STEFANA
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Andrei-Jose PETRESCU
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Cristian MUNTEANU
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Ioana MILITARU
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Systems Biology of Aging
SERVICE DESCRIPTION:
The Systems Biology of Aging Group was founded by Dr. Robi Tacutu in 2016, and is part of the department of Bioinformatics and Structural Biochemistry at the Institute of Biochemistry of the Romanian Academy. The group is currently funded by a recently awarded EUR 1.9 million grant (Romanian/EU co-funded) for the project “Multi-omics Prediction System for Prioritization of Gerontological Interventions”. The main areas of interest in the group include studying biology of ageing/biogerontology, systems biology and bioinformatics, overall the expertise required to acheive these spanning multiple research fields (from bioinformatics to synthetic biology). With a highly multi-disciplinary team, the projects tackeled by the group include both computational aspects (data aggregation and processing, multi-dimensional data analysis, network-based methods, systems theory approaches, deep learning, etc.) as well as wet-lab experiments (in particular in-vivo testing of the computationally predicted interventions).
SERVICE PERSONS:
Gabriela BUNU
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Robi TACUTU
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Research Equipment
Nano LC - MS System - Orbitrap Velos Pro for Proteome Analysis and Compound Identification
CATALOG NAME:
DESCRIPTION:
This high performance LC-MS system allows CID, PQD, HCD and ETD fragmentation and provides high resolution up to 100000 at m/z 400; mass accuracy <1 ppm and peptide limit detection <50 fmol)
PRODUCER:
Thermo Scientific
PRODUCTION YEAR:
2011
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (138.06 kb)
HPLC System Accela 600 for Biomolecular Separations
CATALOG NAME:
DESCRIPTION:
The High Performance Liquid Chromatography System is provided a quaternary pump, fluorescence and UV-Vis detectors and Fraction Collector
PRODUCER:
Thermo Scientific
PRODUCTION YEAR:
2011
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (98.89 kb)
2D Electrophoresis System for Protein Separations
CATALOG NAME:
DESCRIPTION:
The System consists in: Protean II xi Gel Casting equipment, Protean i12 Isoelectric Focusing equipment, EXQuest Spot Cutter equipment, ChemiDoc MP Imaging equipment
PRODUCER:
BioRad
PRODUCTION YEAR:
2012
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Download data sheet file (629.54 kb)
Biacore 3000 Surface Plasmon Resonance System for biocompound interactions
CATALOG NAME:
DESCRIPTION:
The system allows equilibrium constant measurements and analyze binding kinetics. It also can be used to capture proteins from crude mixtures, to monitor enzymatic processes and to screening applications
PRODUCER:
GE Healthcare
PRODUCTION YEAR:
2012
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Biocomputing Center
CATALOG NAME:
DESCRIPTION:
The Center is aimed for Data Storage and Analysis, String and Structural Bioinformatics, Molecular Modeling and Simulation. The Center hardware consists in: 1 HP - HPC Cluster (4 TFlop, 25 TB capacity); 1 Bull - HPC Cluster (0.4 TFlop); 1 HP - Graphic Station ProLiant WS460c; 1 SGI - Graphic Station; 6 HP - Work Stations. Over this hardware we implemented an integrated platform of professional and academic software for: (a) Mass Spectrometry, (b) Proteomics, (c) Bioinformatics, (d) Molecular Modeling, (e) Molecular Simulation, (f) Molecular Docking; (g) Mathematical and Statistical Data Analysis, (h) Software and Database Development.
PRODUCER:
HP, Bull, SGI
PRODUCTION YEAR:
2012
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Simulation Cluster
CATALOG NAME:
DESCRIPTION:
The cluster is aimed at Data Analysis, String and Structural Bioinformatics, Molecular Modeling and Simulation. The cluster hardware consists of: 12 computing stations, equipped with Intel Processors (i7/i9 model), Nvidia GPUs (1080Ti/2080Ti/3080Ti) totaling over 200 TeraFlops of computational power, usable in conformational sampling of large, multi-molecule ensembles.
PRODUCER:
PRODUCTION YEAR:
2017
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
10.001 € – 50.000 €
DATA SHEET:
Phone:
+4(021) 2239069
Fax:
Splaiul Independentei
,
296
,
Bucharest
060031
,
Bucuresti - Sector 6
Romania
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