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BIOEVAL - Laboratory for biocompatibility evaluation of medical materials and devices
Horia Hulubei National Institute for Physics and Nuclear Engineering IFIN-HH
Short link:
https://eeris.eu/
ERIF-2000-000W-0129
846
Visits
BIOEVAL laboratory is part of the Life and Environmental Physics Department in Horia Hulubei National Institute of Physics and Nuclear Engineering (IFIN-HH) and it is applying methods prescribed by ISO 10993 standard used in evaluating the effects of medical materials and devices upon human body. By following the compliance with EU standards, BIOEVAL makes available to the customers a working structure that may offer valid results in the biocompatibility evaluation of medical materials and devic...
Maria Adriana
Acasandrei
macasan@nipne.ro
Dr
SCIENTIFIC TEAM
2
Cosmin MUSTACIOSU
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Iulia Diana SAVU
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Cell Culture Facilities
RI Domain of activity
Animal Facilities
RI Domain of activity
Biocompatibility Evaluation
RI Domain of activity
Research Data Management Plan:
No information available
Access Policy to Research Infrastructure and Related Services:
No information available
Research Services
Cytotoxicity (ISO 10993-5)
SERVICE DESCRIPTION:
Cytotoxicity testing determines the biological reactivity of the mammalian cell lines following contact with the material or the extract of the material. BIOEVAL investigates cytotoxicity by observing cell viability and morphology after exposure of L-929 cell cultures to agent. In accordance with ISO 10993-5 standard, two methods are followed at BIOEVAL: • Evaluation of cell cultures by agar diffusion • Evaluation of cell cultures by elution test
SERVICE PERSONS:
Iulia Diana SAVU
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Irritation (ISO 10993-10)
SERVICE DESCRIPTION:
Irritation determines the likelihood of a material, device, or their extract to cause irritation. BIOEVAL only performs the in vivo primary skin irritation test that is less aggressive, the test material being simply placed between 4-24 hour on the shaved backs of albino rabbits, observed for 72 hours and scored for redness and swelling. The response is categorized as negligible, slight, moderate or severe.
SERVICE PERSONS:
Cosmin MUSTACIOSU
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Sensitization (ISO 10993-10)
SERVICE DESCRIPTION:
This process explores the potential of a material to cause a sensitizing effect or allergenic reaction in a patient over an extended period of exposure. Sensitization is characterized by the fact that reactions are delayed, not localized, and independent of dose. BIOEVAL uses the Kligman Maximization Test to evaluate the sensitizing capacity of the test material in guinea pigs. A sensitization reaction to the test material is scored based on the defined evaluation criteria in ISO 10993-10 standard. The test is performed over a period of six to eight weeks.
SERVICE PERSONS:
Cosmin MUSTACIOSU
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Cellular and Molecular Biophysics and Radiobiology
SERVICE DESCRIPTION:
Spectrophotometry and microscopy laboratories
SERVICE PERSONS:
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Research Equipment
Clean rooms for cell cultures
CATALOG NAME:
DESCRIPTION:
GMP Class C and D cleanrooms that have a Laminar Flow Hood (BioAir Topsafe 1.5) and a CO2 incubator (Thermo Electron Corporation) for handling cell cultures.
PRODUCER:
PRODUCTION YEAR:
2008
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Animal research facility
CATALOG NAME:
DESCRIPTION:
- Animal Housing Room that accommodate caging - Procedure rooms proximate to animal housing room, that allow researcher access under controlled conditions - Storage space for feed, bedding and equipment is incorporated into the operational flow - A penthouse dedicated to mechanical and electronics equipment that separates the maintenance functions from animal care functions
PRODUCER:
PRODUCTION YEAR:
2008
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Spectrophotometry equipments: UV-VIS (2), FTIR with module ATR, fluorimeter, ELISA reader, AAS
CATALOG NAME:
see description
DESCRIPTION:
Cary UV-VIS (Varian), year: 2000 V-770 (Jasco), year: 2016 Tensor 27 (Bruker),year: 2008, module ATR: 2016 Fluoromax 3 (Horiba Jobin), year: 2007 ELISA Reader Mithras LB940 (Berthold Technologies), year 2007 AAS: Nov AA 300 (Anaytik Jena), year 2008 ELISA plate dispenser: Micro Flo Select (Biotek Instruments), year 2008
PRODUCER:
see description
PRODUCTION YEAR:
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Microscopy equipments: optical microscopes, fluorescence microscope
CATALOG NAME:
see description
DESCRIPTION:
Olympus BX51 Olympus IX71 with Till Photonics Polychrome V lamp Inversion fluorescent micropy: Olympus equiped with Nanowizard 4 Bioscience AFM (JPK Instruments)
PRODUCER:
see description
PRODUCTION YEAR:
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Fraction collector
CATALOG NAME:
FRACTION COLLECTOR CHF100SA
DESCRIPTION:
This fraction collector features four different operating modes (simple, peak, window and manual) to suit your application needs. Adjustable sizes of collection vessels provide user flexibility. The standard test tube rack holds 100 tubes with a diameter of 12 to 15 mm. Optional racks are available for other tubes or microfilter plates—contact our Application Specialists for more information.
PRODUCER:
ADVANTEC MFS
PRODUCTION YEAR:
2012
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Real-Time PCR
CATALOG NAME:
LightCycler® 96 Real-Time PCR
DESCRIPTION:
The LightCycler® 96 Instrument is a real-time PCR system for rapid cycling up to 96 samples. Applications include absolute and relative quantification, melting curve analysis, and endpoint genotyping. Precise LightCycler® 96 Instrument thermal homogeneity and cycling speed produce accurate and reproducible results in a very short time. The LightCycler® 96 Instrument’s optical detection system flexibly detects sequence-dependent probes, such as hydrolysis probes and sequence-independent dyes (i.e., SYBR Green I). Multiplex and multicolor capabilities permit the use of up to four different fluorescent dyes. New innovative LightCycler® 96 Application and Instrument Software creates a simple analysis workflow with easy import and export functions, email notifications after each run, online monitoring flexibility, and server-based network interfacing.
PRODUCER:
Roche
PRODUCTION YEAR:
2016
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Flow cytometer
CATALOG NAME:
Cell LabQuanta SC flow cytometer
DESCRIPTION:
Cell Lab Quanta SC is a flow cytometry system that simultaneously measures electronic volume, side scatter and three fluorescent colors to provide unsurpassed population resolution and accurate cell counting. This advanced flow cytometer has multiple excitation wavelengths, including 488 nm laser and a UV light source optimized for excitation at 366, 405, 435 nm. Together with interchangeable filters, the Quanta SC allows flexible fluorochrome selection for a variety of multicolor applications typically only achievable with expensive and complicated systems. Side scatter and Coulter volume make size analysis and fluorescent measurements more precise. Unique user features expand ease-of-use and flexibility.
PRODUCER:
Beckman Coulter
PRODUCTION YEAR:
2009
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Western Blot
CATALOG NAME:
BioSpectrum Imaging System 810
DESCRIPTION:
Chemiluminescence (including 1D and 2D Western Blots, Northern/Southern Blots), fluorescent and colorimetric imaging Fluorescent multiplexed Western blots Assortment of CCD cameras including deeply cooled cameras
PRODUCER:
UVP
PRODUCTION YEAR:
2009
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
plate reader
CATALOG NAME:
Mithras LB 940
DESCRIPTION:
PRODUCER:
BERTHOLD TECHNOLOGIES
PRODUCTION YEAR:
2008
COMMISSIONING DATE:
PRICE RANGE (at the time of purchase)
DATA SHEET:
Phone:
+40214046134
Fax:
+40214574439
Reactorului
,
30
,
Magurele
077125
,
Ilfov
Romania
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